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The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors might bring about an increase in methadone plasma concentrations, which could result in probably lethal respiratory depression. Furthermore, discontinuation of concomitantly utilized cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may additionally brin